Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744713 | 1.00 | ACE (0.55) | ACEPPARGPPARATDP1SLC10A1 | |
| SCHEMBL9594200 | 0.89 | ELANE (0.48) | ACEPPARGPPARATDP1SLC10A1 | |
| SCHEMBL8744711 | 0.89 | ELANE (0.48) | ACEPPARGPPARATDP1SLC10A1 | |
| SCHEMBL8744782 | 0.83 | L3MBTL1 (0.57) | ACE | |
| SCHEMBL8744788 | 0.83 | L3MBTL1 (0.57) | ACE | |
| SCHEMBL8744755 | 0.82 | MAPK1 (0.40) | — | |
| SCHEMBL8744746 | 0.82 | MAPK1 (0.40) | — | |
| SCHEMBL11573687 | 0.80 | ACE (0.64) | ACEPPARGPPARA | |
| SCHEMBL11515368 | 0.80 | ACE (0.63) | ACEPPARGPPARA | |
| SCHEMBL30278522 | 0.79 | ACE (0.61) | ACEPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |