Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | FNTA | P49354 | 4/20 | 0.47 |
| ▸ | FNTB | P49356 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744841 | 1.00 | MEN1 (0.51) | MEN1KMT2AMAPK1ALDH1A1NPSR1 | |
| SCHEMBL8744755 | 0.87 | MAPK1 (0.40) | MEN1KMT2AMAPK1ALDH1A1FNTA | |
| SCHEMBL8744746 | 0.87 | MAPK1 (0.40) | MEN1KMT2AMAPK1ALDH1A1FNTA | |
| SCHEMBL8744792 | 0.85 | USP2 (0.50) | MEN1KMT2AMAPK1USP2 | |
| SCHEMBL9593906 | 0.85 | USP2 (0.50) | MEN1KMT2AMAPK1USP2 | |
| SCHEMBL2324412 | 0.81 | NPSR1 (0.59) | MAPK1ALDH1A1NPSR1FNTAFNTB | |
| SCHEMBL8744787 | 0.78 | LMNA (0.58) | MAPK1ALDH1A1NPSR1FNTAFNTB | |
| SCHEMBL8744796 | 0.78 | LMNA (0.58) | MAPK1ALDH1A1NPSR1FNTAFNTB | |
| SCHEMBL8744819 | 0.78 | MAPK1 (0.56) | MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL8744827 | 0.78 | MAPK1 (0.56) | MEN1KMT2AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |