Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559927 | 0.87 | TP53 (0.60) | TP53POLBALDH1A1TACR1MEN1 | |
| SCHEMBL8744724 | 0.85 | PRSS1 (0.57) | PRSS1PRSS2PRSS3 | |
| SCHEMBL8744720 | 0.85 | PRSS1 (0.57) | PRSS1PRSS2PRSS3 | |
| SCHEMBL8744805 | 0.84 | TACR1 (0.57) | TP53POLBALDH1A1TACR1MEN1 | |
| SCHEMBL9594563 | 0.84 | TACR1 (0.57) | TP53POLBALDH1A1TACR1MEN1 | |
| SCHEMBL9594765 | 0.84 | PPID (0.46) | TP53POLBALDH1A1KMT2ANOS3 | |
| SCHEMBL8744783 | 0.84 | PPID (0.46) | TP53POLBALDH1A1KMT2ANOS3 | |
| SCHEMBL9488184 | 0.83 | TP53 (0.59) | TP53POLBALDH1A1PTGS2TACR1 | |
| SCHEMBL9488182 | 0.83 | TP53 (0.59) | TP53POLBALDH1A1PTGS2TACR1 | |
| SCHEMBL9487298 | 0.83 | TP53 (0.61) | TP53POLBALDH1A1TACR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |