Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594765 | 1.00 | PPID (0.46) | PPIDNOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL9594560 | 0.84 | KMT2A (0.47) | ALDH1A1MAPTHTTKMT2ASLC22A12 | |
| SCHEMBL8744777 | 0.84 | KMT2A (0.47) | ALDH1A1MAPTHTTKMT2ASLC22A12 | |
| SCHEMBL8744789 | 0.84 | GRN (0.56) | ALDH1A1KMT2ASLC22A12LMNATP53 | |
| SCHEMBL8744785 | 0.84 | GRN (0.56) | ALDH1A1KMT2ASLC22A12LMNATP53 | |
| SCHEMBL8744762 | 0.84 | TP53 (0.56) | NOS3NOS1NOS2ALDH1A1KMT2A | |
| SCHEMBL8744727 | 0.82 | KMT2A (0.44) | ALDH1A1MAPTHTTKMT2ASLC22A12 | |
| SCHEMBL9594623 | 0.82 | KMT2A (0.44) | ALDH1A1MAPTHTTKMT2ASLC22A12 | |
| SCHEMBL4426485 | 0.81 | NOS3 (0.51) | NOS3NOS1NOS2ALDH1A1TAS1R3 | |
| SCHEMBL9595460 | 0.81 | LMNA (0.51) | PPIDALDH1A1POLBHPGDTAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |