Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.57 |
| ▸ | FPR2 | P25090 | 1/20 | 0.56 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GPR34 | Q9UPC5 | 3/20 | 0.50 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744724 | 1.00 | PRSS1 (0.57) | PRSS1PRSS2PRSS3FPR2SHMT1 | |
| SCHEMBL8744762 | 0.85 | TP53 (0.56) | PRSS1PRSS2PRSS3 | |
| SCHEMBL10504767 | 0.83 | ITGB3 (0.65) | MMEACEL3MBTL1ITGB3ITGA2B | |
| SCHEMBL4144668 | 0.83 | ITGB3 (0.65) | MMEACEL3MBTL1ITGB3ITGA2B | |
| SCHEMBL4144665 | 0.83 | ITGB3 (0.65) | MMEACEL3MBTL1ITGB3ITGA2B | |
| SCHEMBL17429226 | 0.81 | ACE (0.56) | PRSS1PRSS2PRSS3MMEACE | |
| SCHEMBL8744789 | 0.80 | GRN (0.56) | CA1CA2 | |
| SCHEMBL8744785 | 0.80 | GRN (0.56) | CA1CA2 | |
| SCHEMBL11187302 | 0.80 | PTGS2 (0.61) | FPR2CTSGCMA1CA1CA2 | |
| SCHEMBL4066390 | 0.79 | L3MBTL1 (0.69) | FPR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |