Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.51 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836854 | 0.81 | AKR1B1 (0.45) | AKR1B1SMN1; SMN2KMT2APOLBSHMT1 | |
| SCHEMBL109215 | 0.78 | AKR1B1 (1.00) | AKR1B1SMN1; SMN2KMT2ARECQLADRA2A | |
| SCHEMBL8744812 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2KMT2AP2RX7ATMMEN1 | |
| SCHEMBL13485815 | 0.77 | KMT2A (0.62) | AKR1B1SMN1; SMN2KMT2ARECQLSIGMAR1 | |
| Hydrochloric Acid SCHEMBL1374156 | 0.77 | AKR1B1 (0.95) | AKR1B1SMN1; SMN2KMT2ARECQLADRA2A | |
| SCHEMBL9364446 | 0.77 | AKR1B1 (0.95) | AKR1B1SMN1; SMN2KMT2ARECQLADRA2A | |
| SCHEMBL13329784 | 0.76 | KMT2A (0.62) | AKR1B1SMN1; SMN2KMT2AP2RX7RECQL | |
| SCHEMBL9527443 | 0.76 | KMT2A (0.61) | AKR1B1SMN1; SMN2KMT2AP2RX7RECQL | |
| SCHEMBL25279561 | 0.75 | RECQL (0.68) | AKR1B1SMN1; SMN2KMT2ARECQLATM | |
| SCHEMBL2854479 | 0.75 | KMT2A (0.61) | SMN1; SMN2KMT2APOLBP2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |