SCHEMBL8744790

SCHEMBL8744790

NCC(=O)c1ncccn1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.54
CTNNB1 P35222 5/20 0.50
WNT3A P56704 5/20 0.50
LMNA P02545 2/20 0.38
HTT P42858 1/20 0.38
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
NAPRT Q6XQN6 2/20 0.34
KMT2A Q03164 1/20 0.34
P4HTM Q9NXG6 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GAA P10253 1/20 0.33
HSP90AA1 P07900 1/20 0.33
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HRH1 P35367 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2819700 0.98 P2RX7 (0.52) P2RX7CTNNB1WNT3ALMNAHTT
SCHEMBL5159948 0.76 P2RX7 (0.61) P2RX7CTNNB1WNT3ALMNAHTT
SCHEMBL15096486 0.76 LMNA (0.53) P2RX7CTNNB1WNT3ALMNAHTT
SCHEMBL4550609 0.75 CTNNB1 (0.50) P2RX7CTNNB1WNT3ACES2CES1
SCHEMBL882968 0.75 CTNNB1 (0.50) P2RX7CTNNB1WNT3ALMNAHTT
SCHEMBL6317653 0.75 CTNNB1 (0.50) P2RX7CTNNB1WNT3ALMNAHTT
Bromide SCHEMBL27039764 0.73 CTNNB1 (0.48) P2RX7CTNNB1WNT3ACES2CES1
SCHEMBL6926387 0.73 CES2 (0.59) CTNNB1WNT3ALMNACES2CES1
Hydrochloric Acid SCHEMBL2898558 0.72 CES2 (0.57) CTNNB1WNT3ALMNACES2CES1
Hydrochloric Acid SCHEMBL5422506 0.72 CES2 (0.57) CTNNB1WNT3ALMNACES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0653421-B1 Process for preparing 2-cyanoimidazole compounds ISHIHARA SANGYO KAISHA (JP) 1997-01-15 EP disclosed
US-5552557-A Process for preparing 2-cyanoimidazole compounds by reaction of an amino ketone compound ISHIHARA SANGYO KAISHA, LTD. (JP) 1996-09-03 US disclosed
EP-0653421-A1 Process for preparing 2-cyanoimidazole compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1995-05-17 EP disclosed