Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | FNTA | P49354 | 4/20 | 0.52 |
| ▸ | FNTB | P49356 | 4/20 | 0.52 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744787 | 1.00 | LMNA (0.58) | LMNAPKMNPSR1FNTAFNTB | |
| SCHEMBL9595460 | 0.85 | LMNA (0.51) | LMNAPKMNPSR1ATMCA1 | |
| SCHEMBL8744707 | 0.85 | LMNA (0.51) | LMNAPKMNPSR1ATMCA1 | |
| SCHEMBL2331097 | 0.81 | FNTA (0.61) | NPSR1FNTAFNTBPGGT1BMAPK1 | |
| SCHEMBL2331099 | 0.81 | FNTA (0.61) | NPSR1FNTAFNTBPGGT1BMAPK1 | |
| SCHEMBL11189541 | 0.81 | PTGS2 (0.56) | LMNAPKMFNTAFNTBCA1 | |
| SCHEMBL11189543 | 0.81 | PTGS2 (0.56) | LMNAPKMFNTAFNTBCA1 | |
| SCHEMBL8744789 | 0.80 | GRN (0.56) | LMNACA1CA2MAPK1ALDH1A1 | |
| SCHEMBL8744785 | 0.80 | GRN (0.56) | LMNACA1CA2MAPK1ALDH1A1 | |
| SCHEMBL11615639 | 0.79 | NPSR1 (0.61) | LMNAPKMNPSR1ATMCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |