Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233910 | 0.83 | POLB (0.37) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6233039 | 0.82 | POLB (0.36) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1715175 | 0.79 | FAAH (0.38) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL2600306 | 0.78 | MAPK1 (0.52) | POLBMEN1KMT2ATSHRMAPK1 | |
| SCHEMBL29591678 | 0.78 | MAPK1 (0.52) | POLBMEN1KMT2ATSHRMAPK1 | |
| SCHEMBL6237845 | 0.78 | NQO1 (0.43) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6234105 | 0.77 | ALDH1A1 (0.35) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6234144 | 0.77 | MEN1 (0.36) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL29511366 | 0.76 | GPR3 (0.52) | KMT2ACYP1A2CYP3A4CYP2C19HTT | |
| SCHEMBL159458 | 0.76 | GPR3 (0.52) | KMT2ACYP1A2CYP3A4CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730584-A4 | 3-ACYLAMINOBENZODIAZEPINES | MERCK & CO INC (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0730584-A1 | 3-ACYLAMINOBENZODIAZEPINES | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5428157-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1995-06-27 | — | — | US | disclosed |
| WO-1995014676-A1 | 3-ACYLAMINOBENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| US-4604464-A | Immunomodulatory 3-(substituted aminobenzoyl)-3,4-dihydrophthalazin-1(2H)-ones | PENNWALT CORPORATION (US) | 1986-08-05 | — | — | US | disclosed |
| US-4537966-A | 1-(Aminobenzoyl)-1H-indazol-3-ols | PENNWALT CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |