SCHEMBL8745100

SCHEMBL8745100

C=Cc1ccc(CSCCNC(=S)C(C)C(=O)O)cc1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.43
HPGD P15428 6/20 0.43
LMNA P02545 5/20 0.43
POLB P06746 2/20 0.42
KMT2A Q03164 5/20 0.41
MEN1 O00255 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 3/20 0.40
ALOX12 P18054 3/20 0.40
HTT P42858 2/20 0.40
GAA P10253 2/20 0.40
FOLH1 Q04609 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
KDM4E B2RXH2 1/20 0.37
PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8745102 0.78 ALDH1A1 (0.44) ALDH1A1HPGDLMNAPOLBKMT2A
SCHEMBL8745098 0.74 ALDH1A1 (0.53) ALDH1A1HPGDLMNAPOLBKMT2A
SCHEMBL8745112 0.74 HPGD (0.51) ALDH1A1HPGDLMNAPOLBKMT2A
SCHEMBL8745142 0.72 ALDH1A1 (0.48) ALDH1A1HPGDLMNAPOLBKMT2A
SCHEMBL8434924 0.71 LMNA (0.40) ALDH1A1HPGDLMNAPOLBKMT2A
SCHEMBL5674593 0.70 CYP2C19 (0.64) ALDH1A1HPGDLMNAPOLBKMT2A
SCHEMBL8895030 0.69 EPHX1 (0.46) ALDH1A1HPGDLMNAPOLBSMN1; SMN2
SCHEMBL8745104 0.69 CYP2C19 (0.37) ALDH1A1HPGDLMNAPOLBKMT2A
SCHEMBL6389194 0.69 ALDH1A1 (0.50) ALDH1A1HPGDPOLBKMT2AMEN1
SCHEMBL24067976 0.69 ALDH1A1 (0.56) ALDH1A1HPGDLMNAPOLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0466220-B1 Carboxy containing monomers and polymers and latices prepared from same JOHNSON & JOHNSON CLIN DIAG (US) 1997-01-29 EP claimed
EP-0462670-B1 Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to caboxylated particles & a kit containing same JOHNSON & JOHNSON CLIN DIAG (US) 1996-08-21 EP claimed
EP-0462644-B1 Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use JOHNSON & JOHNSON CLIN DIAG (US) 1995-10-18 EP claimed
US-5210289-A Homo or coploymers for medical diagnosis EASTMAN KODAK COMPANY (US) 1993-05-11 US claimed
US-5155166-A Diagnostic kits for detecting antibodies or antigens; reacting active amine- or sulfhydryl-containing compound with quaternized carboxylic polymers EASTMAN KODAK COMPANY (US) 1992-10-13 US claimed
US-5149737-A Carboxy group extended from polymer surface allows easier attachment of biological substances EASTMAN KODAK COMPANY (US) 1992-09-22 US claimed
US-5147777-A Analysis, diagnosis EASTMAN KODAK COMPANY (US) 1992-09-15 US claimed
EP-0466220-A2 Carboxy containing monomers and polymers and latices prepared from same Johnson & Johnson Clinical Diagnostics, Inc. (US) 1992-01-15 EP claimed
EP-0462670-A1 Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to caboxylated particles & a kit containing same Johnson & Johnson Clinical Diagnostics, Inc. (US) 1991-12-27 EP claimed
EP-0462644-A1 Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use Johnson & Johnson Clinical Diagnostics, Inc. (US) 1991-12-27 EP claimed
EP-0466220-B1 Carboxy containing monomers and polymers and latices prepared from same JOHNSON & JOHNSON CLIN DIAG (US) 1997-01-29 EP disclosed
EP-0462670-B1 Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to caboxylated particles & a kit containing same JOHNSON & JOHNSON CLIN DIAG (US) 1996-08-21 EP disclosed
EP-0530357-B1 ELEMENT AND METHOD FOR NUCLEIC ACID AMPLIFICATION AND DETECTION USING ADHERED PROBES JOHNSON & JOHNSON CLIN DIAG (US) 1995-11-15 EP disclosed
EP-0468585-B1 Biologically active reagent, analytical element and methods for use of the reagent JOHNSON & JOHNSON CLIN DIAG (US) 1995-11-08 EP disclosed
EP-0462644-B1 Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use JOHNSON & JOHNSON CLIN DIAG (US) 1995-10-18 EP disclosed
US-5147777-A Analysis, diagnosis EASTMAN KODAK COMPANY (US) 1992-09-15 US disclosed
EP-0468585-A2 Biologically active reagent, analytical element and methods for use of the reagent Johnson & Johnson Clinical Diagnostics, Inc. (US) 1992-01-29 EP disclosed
EP-0466220-A2 Carboxy containing monomers and polymers and latices prepared from same Johnson & Johnson Clinical Diagnostics, Inc. (US) 1992-01-15 EP disclosed
EP-0462670-A1 Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to caboxylated particles & a kit containing same Johnson & Johnson Clinical Diagnostics, Inc. (US) 1991-12-27 EP disclosed
EP-0462644-A1 Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use Johnson & Johnson Clinical Diagnostics, Inc. (US) 1991-12-27 EP disclosed