SCHEMBL8745139

SCHEMBL8745139

[c]1ccc(CSc2cc[c]cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 10/20 0.44
MAOA P21397 7/20 0.44
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
NPC1 O15118 2/20 0.41
ALDH1A1 P00352 2/20 0.41
RAB9A P51151 2/20 0.41
APP P05067 1/20 0.37
SLC6A4 P31645 1/20 0.36
KDM4E B2RXH2 1/20 0.33
MIF P14174 1/20 0.33
POLB P06746 1/20 0.31
HSD17B10 Q99714 1/20 0.31
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL402875 0.89 MAOA (0.58) MAOBMAOAMEN1KMT2ANPC1
SCHEMBL1712262 0.89 MAOA (0.53) MAOBMAOAMEN1KMT2ANPC1
SCHEMBL694538 0.85 MEN1 (0.61) MAOBMAOAMEN1KMT2ANPC1
SCHEMBL10584239 0.85 MEN1 (0.61) MAOBMAOAMEN1KMT2ANPC1
SCHEMBL8559865 0.80 ALDH1A1 (0.45) MAOBMAOAMEN1KMT2ANPC1
SCHEMBL694407 0.76 CYP1A2 (0.46) MAOBMAOAMEN1KMT2ANPC1
SCHEMBL694408 0.75 MAOA (0.44) MAOBMAOAMEN1KMT2ANPC1
SCHEMBL694551 0.75 DAO (0.50) MAOBMEN1KMT2AALDH1A1LMNA
SCHEMBL693670 0.75 DAO (0.49) NPC1ALDH1A1RAB9AKDM4EPOLB
SCHEMBL387041 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0466220-B1 Carboxy containing monomers and polymers and latices prepared from same JOHNSON & JOHNSON CLIN DIAG (US) 1997-01-29 EP claimed
US-5210289-A Homo or coploymers for medical diagnosis EASTMAN KODAK COMPANY (US) 1993-05-11 US claimed
US-5149737-A Carboxy group extended from polymer surface allows easier attachment of biological substances EASTMAN KODAK COMPANY (US) 1992-09-22 US claimed
EP-0466220-A2 Carboxy containing monomers and polymers and latices prepared from same Johnson & Johnson Clinical Diagnostics, Inc. (US) 1992-01-15 EP claimed
US-5278267-A Water insoluble vinyl aromatic polymer EASTMAN KODAK COMPANY (US) 1994-01-11 US disclosed
US-5210289-A Homo or coploymers for medical diagnosis EASTMAN KODAK COMPANY (US) 1993-05-11 US disclosed
US-5149737-A Carboxy group extended from polymer surface allows easier attachment of biological substances EASTMAN KODAK COMPANY (US) 1992-09-22 US disclosed
EP-0466220-A2 Carboxy containing monomers and polymers and latices prepared from same Johnson & Johnson Clinical Diagnostics, Inc. (US) 1992-01-15 EP disclosed