SCHEMBL8559865

SCHEMBL8559865

CC(C)(C)c1ccc(SCc2cc[c]cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
DAO P14920 1/20 0.40
MAOB P27338 5/20 0.39
MAOA P21397 4/20 0.39
EGFR P00533 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
SCN9A Q15858 3/20 0.38
SCN5A Q14524 2/20 0.38
GRIN2C Q14957 1/20 0.38
APP P05067 1/20 0.37
BCHE P06276 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27684871 0.81 EGFR (0.54) ALDH1A1NPC1RAB9AL3MBTL1SMN1; SMN2
SCHEMBL8745139 0.80 MAOB (0.44) ALDH1A1NPC1RAB9ASMN1; SMN2MAOB
SCHEMBL13406684 0.80 TSHR (0.56) ALDH1A1NPC1RAB9AL3MBTL1SMN1; SMN2
SCHEMBL28501784 0.80 TSHR (0.56) ALDH1A1NPC1RAB9AL3MBTL1SMN1; SMN2
SCHEMBL5368718 0.79 ALDH1A1 (0.61) ALDH1A1NPC1RAB9AL3MBTL1SMN1; SMN2
SCHEMBL10584239 0.76 MEN1 (0.61) ALDH1A1NPC1RAB9AL3MBTL1SMN1; SMN2
SCHEMBL29133328 0.75 ADRA2A (0.43) ALDH1A1SMN1; SMN2APPBCHEACHE
SCHEMBL8560676 0.75 TSHR (0.41) ALDH1A1NPC1RAB9AL3MBTL1SMN1; SMN2
SCHEMBL1712262 0.75 MAOA (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2MAOB
SCHEMBL8458039 0.73 NR1H4 (0.57) ALDH1A1NPC1RAB9AL3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5814646-A TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS ELI LILLY AND COMPANY (US) 1998-09-29 US disclosed