Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | PCNA | P12004 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8745435 | 0.86 | THRA (0.48) | THRATHRBPPARGPCNA | |
| SCHEMBL8745401 | 0.81 | PCNA (0.58) | THRATHRBNR1I2PPARGAGTR2 | |
| SCHEMBL8745404 | 0.81 | PCNA (0.58) | THRATHRBNR1I2PPARGAGTR2 | |
| SCHEMBL7373699 | 0.79 | SLC7A5 (0.54) | SLC7A5 | |
| SCHEMBL31127604 | 0.79 | SLC7A5 (0.54) | SLC7A5 | |
| SCHEMBL2522740 | 0.79 | SLC7A5 (0.54) | SLC7A5 | |
| SCHEMBL8745464 | 0.76 | THRA (0.44) | THRATHRBNR1I2PPARGAGTR2 | |
| SCHEMBL3682167 | 0.75 | PPARG (0.39) | THRATHRBNR1I2PPARGAGTR2 | |
| SCHEMBL3682170 | 0.75 | PPARG (0.39) | THRATHRBNR1I2PPARGAGTR2 | |
| SCHEMBL10466982 | 0.74 | LDHA (0.64) | BLMKMT2AMMP1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612308-B1 | METHOD FOR PREPARING RADIO-IODINATED THYRONINE DERIVATIVES; NOVEL INTERMEDIATES | HENNING BERLIN GMBH (DE) | 1997-02-05 | — | — | EP | disclosed |
| EP-0612308-A1 | METHOD FOR PREPARING RADIO-IODINATED THYRONINE DERIVATIVES; NOVEL INTERMEDIATES. | HENNING BERLIN GMBH (DE) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993009076-A1 | METHOD FOR PREPARING RADIO-IODINATED THYRONINE DERIVATIVES; NOVEL INTERMEDIATES | HENNING BERLIN GMBH CHEMIE- UND PHARMAWERK (DE) | 1993-05-13 | — | — | WO | disclosed |