Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21675747 | 0.64 | PTGS2 (0.72) | PTGS2ALDH1A1 | |
| SCHEMBL6348979 | 0.63 | PTGS2 (0.71) | PTGS2ALDH2PDE4BKMT2AHSP90AA1 | |
| SCHEMBL7256570 | 0.62 | PDE4B (0.46) | PTGS2PDE4BKMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL9766207 | 0.62 | ALDH2 (0.48) | PTGS2ALDH2PDE4BKMT2AGRM2 | |
| SCHEMBL6569636 | 0.60 | ALDH1A1 (0.40) | PTGS2PDE4BKMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL3219657 | 0.59 | POLB (0.44) | KMT2AMAOAGRM2MAOBPARP1 | |
| SCHEMBL592300 | 0.58 | PTGS2 (0.65) | PTGS2PDE4BKMT2AALDH1A1KDM4E | |
| SCHEMBL13824907 | 0.58 | ALDH1A1 (0.47) | PTGS2ALDH2PDE4BKMT2AALDH1A1 | |
| SCHEMBL4869425 | 0.58 | AKT1 (0.35) | MAOAMAOBL3MBTL1KDM4E | |
| Biphenyl SCHEMBL8855942 | 0.57 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755389-A1 | 3 AND 5 ALKYL AND PHENYL 4-(HYDROXY OR ACYLOXY)-ALKYL SUBSTITUTED 2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | Allergan (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028394-A1 | 3 AND 5 ALKYL AND PHENYL 4-(HYDROXY OR ACYLOXY)-ALKYL SUBSTITUTED 2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN (US) | 1995-10-26 | — | — | WO | disclosed |
| US-5451686-A | 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1995-09-19 | — | — | US | disclosed |