SCHEMBL8745886

SCHEMBL8745886

O=C(O)c1cc(Cl)c(F)c([N+](=O)[O-])c1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
TSHR P16473 3/20 0.41
PKM P14618 1/20 0.40
CDK2 P24941 1/20 0.39
KMT2A Q03164 5/20 0.38
MEN1 O00255 4/20 0.38
TDP1 Q9NUW8 2/20 0.37
CYP3A4 P08684 1/20 0.37
ALOX15 P16050 1/20 0.37
KEAP1 Q14145 1/20 0.36
NFE2L2 Q16236 1/20 0.36
DTYMK P23919 1/20 0.36
CASP6 P55212 1/20 0.36
TTR P02766 1/20 0.35
PPOX P50336 1/20 0.35
TP53 P04637 1/20 0.35
CASP1 P29466 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11444981 0.88 ALDH1A1 (0.54) ALDH1A1CYP1A2CYP2D6CYP2C19TSHR
SCHEMBL2687218 0.82 PKM (0.41) ALDH1A1CYP1A2CYP2D6CYP2C19TSHR
SCHEMBL194903 0.82 PKM (0.43) ALDH1A1CYP1A2CYP2D6CYP2C19TSHR
SCHEMBL8596722 0.81 TSHR (0.60) ALDH1A1TSHRKMT2AMEN1TDP1
SCHEMBL12931078 0.79 ALDH1A1 (0.50) ALDH1A1CYP1A2CYP2D6CYP2C19TSHR
SCHEMBL3342909 0.79 ALDH1A1 (0.41) ALDH1A1CYP1A2CYP2D6CYP2C19TSHR
SCHEMBL4357549 0.77 DTYMK (0.44) ALDH1A1CYP1A2CYP2D6CYP2C19TSHR
SCHEMBL4246480 0.76 ALDH1A1 (0.48) ALDH1A1TSHRTDP1CYP3A4ALOX15
SCHEMBL8683261 0.75 KEAP1 (0.44) ALDH1A1TSHRPKMKMT2AMEN1
SCHEMBL8065086 0.75 TSHR (0.59) ALDH1A1CYP1A2CYP2D6CYP2C19TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0655997-A1 PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. ABBOTT LAB (US) 1995-06-07 EP claimed
EP-0655997-A4 PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. ABBOTT LAB (US) 1995-02-10 EP claimed
US-5294721-A Reacting a halonitrobenzene and a pyridinium salt ABBOTT LABORATORIES (US) 1994-03-15 US claimed
WO-1994004502-A1 PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME ABBOTT LABORATORIES (US) 1994-03-03 WO claimed
EP-0655997-B1 PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME ABBOTT LAB (US) 1997-02-12 EP disclosed
EP-0655997-A1 PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. ABBOTT LAB (US) 1995-06-07 EP disclosed
EP-0655997-A4 PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. ABBOTT LAB (US) 1995-02-10 EP disclosed
US-5294721-A Reacting a halonitrobenzene and a pyridinium salt ABBOTT LABORATORIES (US) 1994-03-15 US disclosed
WO-1994004502-A1 PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME ABBOTT LABORATORIES (US) 1994-03-03 WO disclosed