SCHEMBL8745889

SCHEMBL8745889

O=C(O)CC[C@@](O)(Cl)C1CCCCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
LMNA P02545 1/20 0.37
KDM5A P29375 3/20 0.34
PHF8 Q9UPP1 3/20 0.34
KDM2A Q9Y2K7 3/20 0.34
KDM4C Q9H3R0 2/20 0.34
EPHX2 P34913 1/20 0.34
KDM4A O75164 1/20 0.34
KEAP1 Q14145 1/20 0.33
NFE2L2 Q16236 1/20 0.33
EPHX1 P07099 1/20 0.33
THRA P10827 1/20 0.31
THRB P10828 1/20 0.31
HPGD P15428 1/20 0.31
PTGDR2 Q9Y5Y4 2/20 0.31
CYP2D6 P10635 3/20 0.30
CHRM2 P08172 2/20 0.30
CHRM1 P11229 2/20 0.30
CHRM3 P20309 2/20 0.30
KCNH2 Q12809 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8745903 0.77 ALDH1A1 (0.39) ALDH1A1LMNAKDM5APHF8KDM2A
Hydrochloric Acid SCHEMBL8745885 0.76 ALDH1A1 (0.38) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL19148259 0.74 ALDH1A1 (0.40) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL19150278 0.74 ALDH1A1 (0.40) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL2232704 0.72 ALDH1A1 (0.37) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL9129355 0.71 ALDH1A1 (0.35) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL9225076 0.70 ALDH1A1 (0.41) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL29264079 0.69 ALDH1A1 (0.43) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL14289406 0.69 ALDH1A1 (0.36) ALDH1A1LMNAKDM5APHF8KDM2A
SCHEMBL9225516 0.68 ALDH1A1 (0.42) ALDH1A1LMNAKDM5APHF8KDM2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0519763-B1 Cyclohexylbutyric acid derivatives and their use in the production of optically active cyclohexylnorstatine TAKASAGO PERFUMERY CO LTD (JP) 1997-02-05 EP disclosed
US-5502221-A HYPOTENSIVE INTERMEDIATE TAKASAGO INTERNATIONAL CORPORATION (JP) 1996-03-26 US disclosed
US-5442105-A Catalytic hydrogenation, epoxidation, reacting product with trialkylsilyl azide in the presence of a Lewis acid, hydrogenolysis TAKASAGO INTERNATIONAL CORPORATION (JP) 1995-08-15 US disclosed
EP-0519763-A2 Cyclohexylbutyric acid derivatives and their use in the production of optically active cyclohexylnorstatine TAKASAGO INTERNATIONAL CORPORATION (JP) 1992-12-23 EP disclosed