Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.44 |
| ▸ | FNTA | P49354 | 3/20 | 0.42 |
| ▸ | FNTB | P49356 | 3/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356831 | 0.83 | CYP19A1 (0.54) | CYP19A1FNTAFNTBMYCCYP3A4 | |
| SCHEMBL31040275 | 0.78 | TSHR (0.36) | CYP19A1CYP3A4CYP11B1TSHRCYP11B2 | |
| SCHEMBL14033955 | 0.78 | SLC6A3 (0.45) | CYP19A1TSHR | |
| SCHEMBL28752724 | 0.78 | SLC6A3 (0.41) | CYP19A1CYP3A4CYP11B1TSHRCYP11B2 | |
| SCHEMBL2974022 | 0.78 | SLC6A3 (0.45) | CYP19A1CYP11B1TSHRCYP11B2 | |
| SCHEMBL8633394 | 0.78 | SMN1; SMN2 (0.48) | TSHR | |
| SCHEMBL691258 | 0.74 | CA2 (0.52) | CYP19A1CYP3A4CYP11B1TSHRCYP11B2 | |
| SCHEMBL30251242 | 0.72 | CYP19A1 (0.53) | CYP19A1CYP3A4CYP11B1TSHRCYP11B2 | |
| SCHEMBL17338939 | 0.72 | CYP19A1 (0.53) | CYP19A1CYP3A4CYP11B1TSHRCYP11B2 | |
| SCHEMBL8634094 | 0.71 | SLC6A2 (0.40) | CYP3A4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477141-B1 | Heteroarylmethylbenzols aromatase inhibitors | CIBA GEIGY AG (CH) | 1997-02-26 | — | — | EP | disclosed |
| US-5378721-A | AROMATASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1995-01-03 | — | — | US | disclosed |
| US-5246952-A | Antitumor agents | CIBA-GEIGY CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0477141-A1 | Heteroarylmethylbenzols aromatase inhibitors | CIBA-GEIGY AG (CH) | 1992-03-25 | — | — | EP | disclosed |