Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | TTPA | P49638 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950690 | 1.00 | MAPT (0.46) | MAPTLMNAMEN1KMT2AGSTP1 | |
| SCHEMBL8950702 | 0.94 | MAPT (0.49) | MAPTLMNAMEN1KMT2AGSTP1 | |
| SCHEMBL9096216 | 0.87 | NR1I2 (0.48) | MAPTLMNAMEN1KMT2AGSTP1 | |
| SCHEMBL9098891 | 0.87 | NR1I2 (0.48) | MAPTLMNAMEN1KMT2AGSTP1 | |
| SCHEMBL9096706 | 0.87 | NR1I2 (0.48) | MAPTLMNAMEN1KMT2AGSTP1 | |
| SCHEMBL8950664 | 0.86 | ALOX5 (0.47) | ALOX5 | |
| SCHEMBL8746278 | 0.85 | MAPT (0.59) | MAPTLMNAMEN1KMT2AGSTP1 | |
| SCHEMBL8950797 | 0.84 | AKT1 (0.32) | MAPTLMNAMEN1KMT2AGSTP1 | |
| SCHEMBL8950713 | 0.83 | AKT1 (0.52) | LMNANR1I2ALOX5 | |
| SCHEMBL8950693 | 0.81 | MEN1 (0.39) | MAPTLMNAMEN1KMT2AGSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550337-B1 | Tissue protective tocopherol analogs | MERRELL PHARMA INC (US) | 1997-02-12 | — | — | EP | claimed |
| JP-7025867-A | — | — | None | — | — | JP | disclosed |
| JP-H0725867-A | TISSUE PROTECTIVE TOCOPHEROLANALOG | MERRELL DOW PHARMACEUT INC | 1995-01-27 | — | — | JP | disclosed |
| EP-0550337-A1 | Tissue protective tocopherol analogs | MERRELL PHARMACEUTICALS INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550292-A1 | Tissue protective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-07-07 | — | — | EP | disclosed |