Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.52 |
| ▸ | PHLPP1 | O60346 | 3/20 | 0.52 |
| ▸ | ILK | Q13418 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746281 | 0.86 | AKT1 (0.66) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL8950664 | 0.85 | ALOX5 (0.47) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL8950690 | 0.83 | MAPT (0.46) | ALOX5LMNANR1I2 | |
| SCHEMBL8746294 | 0.83 | MAPT (0.46) | ALOX5LMNANR1I2 | |
| SCHEMBL9567442 | 0.80 | AKT1 (0.45) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL8950702 | 0.78 | MAPT (0.49) | ALOX5LMNANR1I2 | |
| SCHEMBL8950797 | 0.78 | AKT1 (0.32) | AKT1ALOX5LMNANR1I2 | |
| SCHEMBL18212526 | 0.73 | AKT1 (0.70) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL14580950 | 0.73 | AKT1 (0.70) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL5771546 | 0.73 | AKT1 (0.70) | AKT1PDPK1PHLPP1ILKALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484810-A | Tissue protective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0550292-A1 | Tissue protective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-07-07 | — | — | EP | disclosed |