Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2629438 | 0.85 | CA12 (0.38) | GAATDP1ALDH1A1LMNAMEN1 | |
| SCHEMBL12212847 | 0.84 | FDPS (0.34) | GAANPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL141088 | 0.81 | TDP1 (0.42) | TDP1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL9854459 | 0.77 | ALDH1A1 (0.45) | GAATDP1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL28255718 | 0.77 | TDP1 (0.45) | GAATDP1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13247628 | 0.76 | GAA (0.36) | GAAANPEPALDH1A1LMNAALOX15 | |
| SCHEMBL8724279 | 0.75 | GAA (0.44) | GAAALDH1A1CYP3A4TSHRALOX12 | |
| SCHEMBL3955074 | 0.73 | GAA (0.55) | GAANPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4740890 | 0.73 | GAA (0.55) | GAANPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL16265022 | 0.72 | KMT2A (0.47) | GAASMN1; SMN2ALDH1A1ALOX15L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785494-B2 | Calcium sensing receptor modulating compounds and pharmaceutical use thereof | LEO-PHARMA A/S (DK) | 2014-07-22 | — | — | US | disclosed |
| US-20120129926-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129926-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | CASR, CALCR, ORAI1 | GAA 2639/4885TDP1 3771/4885KCNH3 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.