Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747329 | 0.81 | PKM (0.45) | MEN1KMT2AADRA1DADRA1AADRA1B | |
| SCHEMBL8747178 | 0.76 | CHRNA7 (0.48) | ADRA1DADRA1AADRA1BCHRNA7 | |
| SCHEMBL17375771 | 0.72 | NPC1 (0.42) | MEN1KMT2ASIRT2SMN1; SMN2CHRNA7 | |
| SCHEMBL8747147 | 0.69 | PKM (0.46) | MEN1KMT2ACHRNA7 | |
| SCHEMBL8747269 | 0.66 | KDM4E (0.45) | MEN1KMT2ACHRNA7 | |
| SCHEMBL8747338 | 0.65 | PKM (0.44) | MEN1KMT2ACHRNA7 | |
| SCHEMBL8746992 | 0.64 | MEN1 (0.46) | MEN1KMT2ACHRNA7 | |
| Bromide SCHEMBL8747077 | 0.64 | MEN1 (0.45) | MEN1KMT2ACHRNA7 | |
| SCHEMBL8747218 | 0.63 | CHRNA7 (0.50) | CHRNA7 | |
| SCHEMBL29993463 | 0.62 | CHRNA7 (0.45) | SMN1; SMN2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618900-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| US-5519034-A | ANALGESICS | THE BOOTS COMPANY PLC (GB) | 1996-05-21 | — | — | US | disclosed |
| EP-0618900-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS. | BOOTS CO PLC (GB) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013073-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |