Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747158 | 0.72 | MEN1 (0.36) | SMN1; SMN2SIRT2CHRNA7MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11639609 | 0.72 | CA2 (0.44) | HSD17B10MAPK1ALDH1A1 | |
| SCHEMBL8556952 | 0.69 | MEN1 (0.60) | NPC1RAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL8554816 | 0.69 | MAPK1 (0.59) | NPC1RAB9AHSD17B10MAPK1SMN1; SMN2 | |
| SCHEMBL8554822 | 0.68 | MAPK1 (0.64) | NPC1RAB9AHSD17B10MAPK1HPGD | |
| SCHEMBL5653057 | 0.68 | NPC1 (0.64) | NPC1RAB9AHSD17B10MAPK1HPGD | |
| SCHEMBL29993463 | 0.67 | CHRNA7 (0.45) | NPC1RAB9AHSD17B10MAPK1HPGD | |
| SCHEMBL11718272 | 0.67 | KMT2A (0.79) | MAPK1CHRNA7MEN1KMT2AALDH1A1 | |
| SCHEMBL18721789 | 0.67 | SIRT2 (0.42) | HSD17B10SIRT2CTSVCTSLSRD5A1 | |
| SCHEMBL3051394 | 0.66 | CHRNA7 (0.50) | NPC1RAB9AHSD17B10MAPK1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015197550-A1 | NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2015-12-30 | — | — | WO | disclosed |