Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.62 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.62 |
| ▸ | PREP | P48147 | 3/20 | 0.61 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747160 | 1.00 | KLK7 (0.62) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL16272917 | 0.91 | FKBP1A (0.66) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL7326760 | 0.91 | FKBP1A (0.66) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL4724457 | 0.87 | PREP (0.67) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL839568 | 0.87 | KLK7 (0.62) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL630112 | 0.87 | PREP (0.67) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL5525089 | 0.87 | PREP (0.67) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL205223 | 0.87 | PREP (0.67) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL29553 | 0.87 | PREP (0.67) | KLK7KLK5PREPCTRB1NPSR1 | |
| SCHEMBL475715 | 0.87 | PREP (0.67) | KLK7KLK5PREPCTRB1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618900-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1997-03-12 | — | — | EP | disclosed |