SCHEMBL8747170

SCHEMBL8747170

FC(F)=C(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.48
LMNA P02545 1/20 0.36
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
MMP1 P03956 1/20 0.31
MMP2 P08253 1/20 0.31
MMP9 P14780 1/20 0.31
MMP8 P22894 1/20 0.31
MMP13 P45452 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28858567 0.95 THRB (0.44) THRBLMNA
SCHEMBL8747239 0.87 THRB (0.42) THRBLMNA
SCHEMBL28497879 0.86 THRB (0.40) THRB
SCHEMBL28503131 0.82 THRB (0.31) THRB
Perflexane SCHEMBL3018244 0.77 LMNA (0.47) THRBLMNACA1CA2MMP1
SCHEMBL471746 0.77 THRB (0.31) THRB
SCHEMBL6664831 0.77 THRB (0.48) THRBLMNACA1CA2MMP1
SCHEMBL1033285 0.77 THRB (0.48) THRBLMNACA1CA2MMP1
SCHEMBL161264 0.77 THRB (0.48) THRBLMNACA1CA2MMP1
SCHEMBL12486010 0.77 THRB (0.48) THRBLMNACA1CA2MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0515676-B1 SYSTEM FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS MALLINCKRODT MEDICAL INC (US) 1997-03-12 EP claimed
US-5213570-A System and method for oxygenation of the pericardium MALLINCKRODT MEDICAL, INC. (US) 1993-05-25 US claimed
EP-0515676-A1 SYSTEM AND METHOD FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS. MALLINCKRODT MEDICAL INC (US) 1992-12-02 EP claimed
US-5137510-A SYSTEM AND METHOD FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS MALLINCKRODT MEDICAL, INC. (US) 1992-08-11 US claimed
WO-1992010221-A2 SYSTEM AND METHOD FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS MALLINCKRODT MEDICAL, INC. (US) 1992-06-25 WO claimed
EP-0515676-B1 SYSTEM FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS MALLINCKRODT MEDICAL INC (US) 1997-03-12 EP disclosed
US-5213570-A System and method for oxygenation of the pericardium MALLINCKRODT MEDICAL, INC. (US) 1993-05-25 US disclosed
EP-0515676-A1 SYSTEM AND METHOD FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS. MALLINCKRODT MEDICAL INC (US) 1992-12-02 EP disclosed
US-5137510-A SYSTEM AND METHOD FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS MALLINCKRODT MEDICAL, INC. (US) 1992-08-11 US disclosed
WO-1992010221-A2 SYSTEM AND METHOD FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS MALLINCKRODT MEDICAL, INC. (US) 1992-06-25 WO disclosed