SCHEMBL8747239

SCHEMBL8747239

FC(F)=C(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.42
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8747170 0.87 THRB (0.48) THRBLMNA
SCHEMBL28858567 0.82 THRB (0.44) THRBLMNA
SCHEMBL28497879 0.79 THRB (0.40) THRB
SCHEMBL28503064 0.78
SCHEMBL31633902 0.72
Perflexane SCHEMBL3018244 0.71 LMNA (0.47) THRBLMNA
SCHEMBL471746 0.70 THRB (0.31) THRB
SCHEMBL1033285 0.70 THRB (0.48) THRBLMNA
SCHEMBL161264 0.70 THRB (0.48) THRBLMNA
SCHEMBL157953 0.70 THRB (0.48) THRBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0515676-B1 SYSTEM FOR OXYGENATION OF THE HEART USING SUBPERICARDIAL FLUIDS MALLINCKRODT MEDICAL INC (US) 1997-03-12 EP claimed