Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TTPA | P49638 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 5/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279085 | 0.85 | NR1I2 (0.41) | MAPTLMNATTPAMEN1GSTP1 | |
| SCHEMBL4285412 | 0.82 | NR1I2 (0.38) | MAPTLMNATTPAMEN1GSTP1 | |
| SCHEMBL8746263 | 0.82 | MAPT (0.37) | MAPTLMNATTPAMEN1GSTP1 | |
| SCHEMBL4271053 | 0.81 | ALOX5 (0.47) | MAPTLMNATTPAMEN1GSTP1 | |
| Bromide SCHEMBL8603327 | 0.81 | LMNA (0.44) | MAPTLMNATTPAMEN1GSTP1 | |
| Bromide SCHEMBL9096853 | 0.81 | NR1I2 (0.38) | MAPTLMNATTPAMEN1GSTP1 | |
| SCHEMBL15833932 | 0.78 | AKT1 (0.55) | MAPTLMNATTPAMEN1GSTP1 | |
| SCHEMBL8747784 | 0.77 | MAPT (0.59) | MAPTLMNATTPAMEN1GSTP1 | |
| SCHEMBL8747773 | 0.77 | ALOX5 (0.56) | MAPTLMNATTPAMEN1GSTP1 | |
| SCHEMBL1258674 | 0.76 | LMNA (0.67) | MAPTLMNATTPAMEN1GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586518-B1 | CHOLESTEROL-LOWERING TOCOPHEROL ANALOGS | MERRELL PHARMA INC (US) | 1997-03-12 | — | — | EP | claimed |
| US-5135945-A | Cholesterol-lowering tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-04 | — | — | US | claimed |
| EP-0586518-B1 | CHOLESTEROL-LOWERING TOCOPHEROL ANALOGS | MERRELL PHARMA INC (US) | 1997-03-12 | — | — | EP | disclosed |
| EP-0369874-B1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMA (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5135945-A | Cholesterol-lowering tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0369874-A2 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0369082-A1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |