SCHEMBL8748009

SCHEMBL8748009

CCCCCCC1CCC(CCC2CCC(CCc3cc(F)c(C(F)(F)F)c(F)c3)CC2)CC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.35
CYP3A4 P08684 1/20 0.34
CYP2C8 P10632 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
S1PR3 Q99500 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
CNR2 P34972 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
PTGS2 P35354 2/20 0.32
ITGB3 P05106 1/20 0.32
ITGA2B P08514 1/20 0.32
CYP1A2 P05177 2/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8748047 1.00 DAO (0.35) DAOCYP3A4CYP2C8CYP2D6CYP2C9
SCHEMBL8747987 0.99 DAO (0.36) DAOCYP3A4CYP2C8CYP2D6CYP2C9
SCHEMBL8748183 0.94 CYP1A2 (0.37) DAOCYP3A4KMT2ACNR2PTGS2
SCHEMBL13636530 0.92 PTGS2 (0.38) DAOCYP3A4CYP2C8CYP2D6CYP2C9
SCHEMBL8031324 0.88 DAO (0.38) DAOCYP2C9HTR2AHTR2CHTR2B
SCHEMBL9764292 0.87 CYP3A4 (0.36) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL9764286 0.87 CYP3A4 (0.36) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL9764321 0.87 CYP3A4 (0.36) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL9764284 0.87 CYP3A4 (0.36) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL9764020 0.87 CYP3A4 (0.36) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0761799-A1 Liquid crystalline compound substituted with fluorine containing group, liquid crystal composition, and liquid crystal display device Chisso Corporation (JP) 1997-03-12 EP disclosed