Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8748252 | 1.00 | GAA (0.55) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8747936 | 0.88 | GAA (0.47) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8747934 | 0.88 | GAA (0.47) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8748028 | 0.87 | RAB9A (0.47) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8748025 | 0.87 | RAB9A (0.47) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL9699605 | 0.86 | PRMT1 (0.56) | RAB9ANPC1LMNAMAPTALOX15 | |
| SCHEMBL8748042 | 0.84 | ALDH1A1 (0.50) | GAANPC1TP53MAPTMLYCD | |
| SCHEMBL8748258 | 0.83 | GAA (0.63) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8748256 | 0.83 | GAA (0.63) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8994976 | 0.83 | ALDH1A1 (0.52) | RAB9ANPC1LMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601977-B1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor antagonists | CIBA GEIGY AG (CH) | 1997-01-22 | — | — | EP | disclosed |
| US-5455274-A | Leukotriene antagonists; treating rheumatoid arthritis | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0601977-A1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor anagonists | CIBA-GEIGY AG (CH) | 1994-06-15 | — | — | EP | disclosed |