Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874907 | 0.90 | NAMPT (0.47) | NAMPTKITATRHDAC1CHRNA7 | |
| SCHEMBL875445 | 0.88 | NAMPT (0.46) | NAMPTKITATRHDAC1CHRNA7 | |
| SCHEMBL875943 | 0.88 | NAMPT (0.48) | NAMPTKITATRHDAC1CHRNA7 | |
| SCHEMBL874909 | 0.86 | CHRNA7 (0.47) | NAMPTKITATRHDAC1CHRNA7 | |
| SCHEMBL875016 | 0.82 | NAMPT (0.41) | NAMPTKITATRHDAC1JAK2 | |
| SCHEMBL882909 | 0.79 | NAMPT (0.49) | NAMPTKITHDAC1CHRNA7CHRM1 | |
| SCHEMBL875403 | 0.78 | NAMPT (0.53) | NAMPTKITATRHDAC1CHRM1 | |
| SCHEMBL3046675 | 0.78 | NAMPT (0.46) | NAMPTKITATRHDAC1CHRNA7 | |
| SCHEMBL875099 | 0.77 | NAMPT (0.53) | NAMPTCHRNA7 | |
| SCHEMBL3055571 | 0.77 | NAMPT (0.49) | NAMPTKITATRHDAC1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |