Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874907 | 0.93 | NAMPT (0.47) | NAMPTHDAC1KITJAK2ATR | |
| SCHEMBL875705 | 0.85 | NAMPT (0.47) | NAMPTHDAC1CPB1ROCK2 | |
| SCHEMBL875445 | 0.84 | NAMPT (0.46) | NAMPTHDAC1KITJAK2ATR | |
| SCHEMBL875943 | 0.82 | NAMPT (0.48) | NAMPTHDAC1KITJAK2ATR | |
| SCHEMBL874894 | 0.82 | NAMPT (0.46) | NAMPTHDAC1KITJAK2ATR | |
| SCHEMBL3051319 | 0.81 | NAMPT (0.40) | NAMPTHDAC1KITJAK2ROCK2 | |
| SCHEMBL874909 | 0.80 | CHRNA7 (0.47) | NAMPTHDAC1KITJAK2ATR | |
| SCHEMBL875170 | 0.80 | HDAC1 (0.41) | NAMPTHDAC1KITJAK2ROCK2 | |
| SCHEMBL875967 | 0.78 | NAMPT (0.40) | NAMPTHDAC1KITCPB1ROCK2 | |
| SCHEMBL874781 | 0.76 | HDAC6 (0.48) | NAMPTHDAC1CPB1ROCK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |