SCHEMBL8749217

SCHEMBL8749217

CC(C)OC(=O)C(C)OC(=O)[C@@H]1CCC(=O)N1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.43
GAA P10253 1/20 0.41
CNR1 P21554 1/20 0.40
DAGLA Q9Y4D2 1/20 0.40
POLB P06746 1/20 0.39
TSHR P16473 1/20 0.38
HCRTR2 O43614 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
THRB P10828 1/20 0.32
PPARG P37231 1/20 0.31
NCOA2 Q15596 1/20 0.31
NCOA1 Q15788 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
NCOA3 Q9Y6Q9 1/20 0.31
ACACB O00763 1/20 0.31
IRAK4 Q9NWZ3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2241494 0.89 LMNA (0.45) LMNAGAACNR1DAGLAPOLB
SCHEMBL8801791 0.89 LMNA (0.45) LMNAGAACNR1DAGLAPOLB
SCHEMBL3769213 0.89 LMNA (0.45) LMNAGAACNR1DAGLAPOLB
SCHEMBL7635759 0.85 LMNA (0.47) LMNAGAACNR1DAGLAPOLB
SCHEMBL8749155 0.84 LMNA (0.42) LMNAGAACNR1DAGLAPOLB
SCHEMBL8749152 0.84 LMNA (0.42) LMNAGAACNR1DAGLAPOLB
SCHEMBL8761598 0.83 CNR1 (0.44) LMNAGAACNR1DAGLAPOLB
SCHEMBL9470400 0.83 LMNA (0.43) LMNAGAACNR1DAGLAPOLB
SCHEMBL10632345 0.80 LMNA (0.39) LMNAGAACNR1DAGLAPOLB
SCHEMBL7632267 0.80 LMNA (0.40) LMNAGAACNR1DAGLAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0342056-B1 Cosmetic composition UNILEVER PLC (GB) 1994-08-17 EP claimed
EP-0277428-B1 Cosmetic composition UNILEVER PLC (GB) 1994-03-23 EP claimed
EP-0342054-B1 Cosmetic composition UNILEVER PLC (GB) 1993-11-03 EP claimed
EP-0342055-A2 Use of pyroglutamic acid alkyl esters for the manufacture of a medicament for the treatment of ichthyosis UNILEVER PLC (GB) 1989-11-15 EP claimed
EP-0342054-A2 Cosmetic composition UNILEVER PLC (GB) 1989-11-15 EP claimed
EP-0342056-A2 Cosmetic composition UNILEVER PLC (GB) 1989-11-15 EP claimed
EP-0176217-B1 PYROGLUTAMIC ACID ESTERS, THEIR SYNTHESIS AND USE IN TOPICAL PRODUCTS UNILEVER PLC (GB) 1989-06-07 EP claimed
US-4774255-A SKIN DISORDERS LEVER BROTHERS COMPANY (US) 1988-09-27 US claimed
EP-0277428-A2 Cosmetic composition UNILEVER PLC (GB) 1988-08-10 EP claimed
EP-0446047-B1 Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors UNILEVER PLC (GB) 1997-06-11 EP disclosed
EP-0571198-B1 Cosmetic composition containing hair-growth promoter UNILEVER PLC (GB) 1997-03-19 EP disclosed
EP-0572167-B1 Cosmetic composition UNILEVER PLC (GB) 1996-10-09 EP disclosed
US-5559092-A HAIR GROWTH, GLUTAMINE DIPEPTIDE CHESEBROUGH-POND'S USA CO. DIVISION OF CONOPCO, INC. (US) 1996-09-24 US disclosed
EP-0490581-B1 Cosmetic composition UNILEVER PLC (GB) 1996-05-22 EP disclosed
EP-0334586-A1 Carbohydrate lactam derivatives and their use in cosmetic compositions UNILEVER PLC (GB) 1989-09-27 EP disclosed
EP-0334585-A2 Cosmetic composition UNILEVER PLC (GB) 1989-09-27 EP disclosed
EP-0176217-B1 PYROGLUTAMIC ACID ESTERS, THEIR SYNTHESIS AND USE IN TOPICAL PRODUCTS UNILEVER PLC (GB) 1989-06-07 EP disclosed
US-4832946-A CELL CULTURE FOR HAIR GROWTH CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC., A CORP. OF NY 1989-05-23 US disclosed
EP-0277428-A2 Cosmetic composition UNILEVER PLC (GB) 1988-08-10 EP disclosed
EP-0272920-A1 Cosmetic composition UNILEVER PLC (GB) 1988-06-29 EP disclosed