Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976886 | 0.86 | FABP4 (0.65) | MEN1KMT2AFABP4SIRT2MAPT | |
| SCHEMBL10516141 | 0.83 | PTGS2 (0.52) | MEN1KMT2AFABP4SIRT2MAPT | |
| SCHEMBL5680799 | 0.83 | FABP4 (0.71) | MEN1KMT2AFABP4SIRT2MAPT | |
| SCHEMBL5992131 | 0.81 | SIRT2 (0.67) | FABP4SIRT2 | |
| SCHEMBL874936 | 0.81 | MAPT (0.47) | MEN1KMT2AFABP4MAPTALOX15 | |
| SCHEMBL10515711 | 0.80 | MEN1 (0.65) | MEN1KMT2AMAPTALOX15KDM4E | |
| SCHEMBL5993324 | 0.79 | MAPT (0.76) | KMT2AFABP4SIRT2MAPTALOX15 | |
| SCHEMBL10517602 | 0.76 | KMT2A (0.54) | MEN1KMT2AMAPTKDM4EGAA | |
| SCHEMBL10518154 | 0.73 | MT-CO2 (0.63) | MEN1KMT2ASIRT2MAPTKDM4E | |
| SCHEMBL18109767 | 0.72 | FABP4 (0.85) | MEN1KMT2AFABP4SIRT2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292181-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTIONS | GEORGE MASON INTELLECTUAL PROPERTIES, INC. | 2010-11-18 | — | — | US | claimed |
| EP-2236620-A2 | Compositions and methods for detecting and treating HIV infection | George Mason Intellectual Properties, Inc. (US) | 2010-10-06 | — | — | EP | claimed |
| EP-2021496-A2 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTION | George Mason Intellectual Properties, Inc. (US) | 2009-02-11 | — | — | EP | claimed |
| US-20080064026-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTIONS | CENTER FOR APPLIED PROTEOMICS & MOLECULAR MEDICINE | 2008-03-13 | — | — | US | claimed |
| WO-2007130523-A2 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTION | GEORGE MASON INTELLECTUAL PROPERTIES, INC. (US) | 2007-11-15 | — | — | WO | claimed |
| CN-104788365-B | Pyrazinamide derivative, preparation method and application | 上海艾力斯医药科技有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-104788365-A | Isonicotinamide derivative, preparation method and applications thereof | ALLIST PHARMACEUTICALS INC | 2015-07-22 | — | — | CN | disclosed |
| EP-1301472-B1 | OXYGENATED ESTERS OF 4-IODO PHENYLAMINO BENZHYDROXAMIC ACIDS | WARNER LAMBERT CO (US) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012040579-A2 | MOLECULAR SCREENING ACROSS DEFINED STIFFNESS MATRICES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-29 | — | — | WO | disclosed |
| US-20100292181-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTIONS | GEORGE MASON INTELLECTUAL PROPERTIES, INC. | 2010-11-18 | — | — | US | disclosed |
| EP-2236620-A2 | Compositions and methods for detecting and treating HIV infection | George Mason Intellectual Properties, Inc. (US) | 2010-10-06 | — | — | EP | disclosed |
| US-7662547-B2 | Compositions and methods for detecting and treating HIV infections | GEORGE MASON INTELLECTUAL PROPERTIES, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000037141-A1 | COMBINATION CHEMOTHERAPY | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |
| WO-2000035435-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |
| WO-2000035436-A2 | TREATMENT OF ARTHRITIS WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |
| EP-0993439-A1 | 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001426-A1 | 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |
| WO-1998037881-A1 | METHOD OF TREATING OR PREVENTING SEPTIC SHOCK BY ADMINISTERING A MEK INHIBITOR | WARNER LAMBERT COMPANY (US) | 1998-09-03 | — | — | WO | disclosed |