Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875615 | 0.90 | NAMPT (0.45) | HDAC6NAMPTHDAC1CPB1ROCK2 | |
| SCHEMBL875402 | 0.87 | NAMPT (0.45) | HDAC6NAMPTHDAC1CPB1ROCK2 | |
| SCHEMBL875709 | 0.85 | NAMPT (0.44) | HDAC6NAMPTHDAC1ROCK2 | |
| SCHEMBL875705 | 0.78 | NAMPT (0.47) | NAMPTHDAC1CPB1ROCK2POLB | |
| SCHEMBL874907 | 0.77 | NAMPT (0.47) | NAMPTHDAC1 | |
| SCHEMBL875445 | 0.76 | NAMPT (0.46) | NAMPTHDAC1 | |
| SCHEMBL875016 | 0.76 | NAMPT (0.41) | NAMPTHDAC1CPB1ROCK2KDR | |
| SCHEMBL3048653 | 0.74 | TYRO3 (0.51) | — | |
| SCHEMBL875943 | 0.71 | NAMPT (0.48) | NAMPTHDAC1POLB | |
| SCHEMBL874894 | 0.71 | NAMPT (0.46) | NAMPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |