Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874813 | 0.92 | NAMPT (0.48) | NAMPTHDAC1ATRMEN1POLB | |
| SCHEMBL875967 | 0.89 | NAMPT (0.40) | NAMPTHDAC1ATR | |
| SCHEMBL874755 | 0.81 | NAMPT (0.47) | NAMPTHDAC1ATRMEN1POLB | |
| SCHEMBL875170 | 0.81 | HDAC1 (0.41) | NAMPTHDAC1 | |
| SCHEMBL874266 | 0.79 | NAMPT (0.49) | NAMPTHDAC1ATRMEN1POLB | |
| SCHEMBL3051507 | 0.78 | ATR (0.50) | NAMPTHDAC1ATRMEN1POLB | |
| SCHEMBL3051319 | 0.77 | NAMPT (0.40) | NAMPTHDAC1ATR | |
| SCHEMBL874795 | 0.76 | NAMPT (0.47) | NAMPTHDAC1ATR | |
| SCHEMBL883091 | 0.76 | NAMPT (0.36) | NAMPTHDAC1 | |
| SCHEMBL875016 | 0.75 | NAMPT (0.41) | NAMPTHDAC1ATRAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |