Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038512 | 0.80 | RAB9A (0.52) | TSHRCYP2D6KDM4EHPGDALDH1A1 | |
| SCHEMBL1680823 | 0.79 | LMNA (0.57) | CYP1A2CYP2C19TSHRCYP3A4CYP2D6 | |
| SCHEMBL510619 | 0.76 | HTT (0.58) | CYP1A2TSHRCYP2D6ABCB1ABCG2 | |
| SCHEMBL22191457 | 0.76 | KDM4E (0.50) | CYP1A2CYP2C19CYP3A4CYP2D6ABCB1 | |
| SCHEMBL22191849 | 0.76 | LRRK2 (0.49) | CYP1A2CYP2C19TSHRCYP3A4CYP2D6 | |
| SCHEMBL2064845 | 0.76 | SMN1; SMN2 (0.54) | CHRNB2CHRNA4GABRG2GABRB3GABRA5 | |
| SCHEMBL21591750 | 0.76 | LTA4H (0.49) | CHRNB2CHRNA4KDM4EHPGDLTA4H | |
| SCHEMBL6772345 | 0.76 | KCNH2 (0.56) | CHRNB2CHRNA4HPGDLTA4HKCNH2 | |
| SCHEMBL13743125 | 0.76 | KCNH2 (0.56) | CYP1A2CYP2C19CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL8750751 | 0.75 | CHEK1 (0.42) | GABRG2GABRB3GABRA5GABRA3EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1043760-C | \"Pyridinecarboximidamide compounds and the use thereof\ | KIRN BEER KABUSHIKI KAISHA (JP) | 1999-06-23 | — | — | CN | disclosed |
| EP-0634400-B1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BREWERY (JP) | 1997-04-02 | — | — | EP | disclosed |
| US-5508293-A | TREATING HYPERTENSION, ANGINA PECTORIS | KIRIN BEER KABUSHIKI KAISHA (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0634400-A1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BEER KABUSHIKI KAISHA (JP) | 1995-01-18 | — | — | EP | disclosed |
| CN-1077949-A | Pyridine carboxy imido acid amide compound and application thereof | KIRIN BREWERY (JP) | 1993-11-03 | — | — | CN | disclosed |