Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 9/20 | 0.51 |
| ▸ | MAOA | P21397 | 7/20 | 0.51 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29438605 | 1.00 | CA9 (0.62) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL4462879 | 0.89 | MAPT (0.58) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL426336 | 0.85 | NPC1 (0.55) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL14188941 | 0.84 | CA9 (0.45) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL31478025 | 0.82 | AHR (0.61) | CA9MAOBMAOACRBNSMYD3 | |
| SCHEMBL1833499 | 0.82 | AHR (0.61) | CA9MAOBMAOACRBNSMYD3 | |
| SCHEMBL14188943 | 0.79 | MAOA (0.46) | CA9MAOBMAOAPBRM1CRBN | |
| Hydrochloric Acid SCHEMBL27809974 | 0.78 | CA9 (0.54) | CA9NPC1MAPK13MAPK12MAPK11 | |
| Phenol SCHEMBL6582797 | 0.78 | NPC1 (0.56) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8103853 | 0.77 | CA9 (0.62) | CA9NPC1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 536 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116789596-A | 2,6,10, 14-tetramethyl pentadecane derivative compound and preparation method and application thereof | 南京师范大学 | 2023-09-22 | — | — | CN | claimed |
| CN-115340494-A | Synthesis method of high-purity aripiprazole | 安徽修一制药有限公司 | 2022-11-15 | — | — | CN | claimed |
| CN-112745262-B | Preparation method of brexpiprazole intermediate 7-hydroxy-1H-quinoline-2-ketone | 江苏恩华药业股份有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-113214150-A | Synthesis of high-purity aripiprazole and preparation method of hydrate particles thereof | 北京逸诚医药科技有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-107525877-B | Method for separating and determining brexpiprazole and impurities thereof by adopting liquid chromatography | 重庆医药工业研究院有限责任公司 | 2021-08-03 | — | — | CN | claimed |
| CN-112745262-A | Preparation method of brexpiprazole intermediate 7-hydroxy-1H-quinoline-2-ketone | 江苏恩华药业股份有限公司 | 2021-05-04 | — | — | CN | claimed |
| CN-112479999-A | Synthetic method of medical intermediate for preparing mental drugs | 谢小芬 | 2021-03-12 | — | — | CN | claimed |
| CN-110128336-A | A kind of preparation method of Aripiprazole | 岳阳新华达制药有限公司 | 2019-08-16 | — | — | CN | claimed |
| US-10092786-B2 | Fire extinguishing composition comprising aldoketones compound | XI'AN WESTPEACE FIRE TECHNOLOGY CO., LTD. (CN) | 2018-10-09 | — | — | US | claimed |
| US-20180155290-A1 | Improved Process for the Preparation of Aripiprazole with Reduced Particle Size | RAO, Davuluri Ramamohan (IN) | 2018-06-07 | — | — | US | claimed |
| CN-1303068-C | Preparation of Alipioxazole | NO 2 MILITARY MEDICAL UNIV P L (CN) | 2007-03-07 | — | — | CN | claimed |
| US-20060258869-A1 | Process for the preparation of aripiprazole | ALEMBIC LIMITED (IN) | 2006-11-16 | — | — | US | claimed |
| CN-1784385-A | Process for the preparation of carbostyril derivatives, such as aripiprazole and its intermediates | DELMAR CHEMICALS INC (CA) | 2006-06-07 | — | — | CN | claimed |
| US-20060079690-A1 | Processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone and the use in aripiprazole preparation thereof | CHEMAGIS LTD. (IL) | 2006-04-13 | — | — | US | claimed |
| WO-2006030446-A1 | PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS | MATRIX LABORATORIES LTD (IN) | 2006-03-23 | — | — | WO | claimed |
| WO-2006001846-A1 | METHOD OF MAKING 7-(4-BROMOBUTOXY)-3,4-DIHYDROCARBOSTYRIL | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-01-05 | — | — | WO | claimed |
| CN-1680328-A | Preparation of Alipioxazole | NO 2 MILITARY MEDICAL UNIV P L (CN) | 2005-10-12 | — | — | CN | claimed |
| US-20050215585-A1 | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-09-29 | — | — | US | claimed |
| CN-1618791-A | New synthesis method of alipirazole | SHANGHAI TEHUA MEDICINE SCIENC (CN) | 2005-05-25 | — | — | CN | claimed |
| CN-1513838-A | Pot cooking sythesis method of alipyracole | 江苏吴中苏药医药开发有限责任公司 | 2004-07-21 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155290-A1 | Improved Process for the Preparation of Aripiprazole with Reduced Particle Size | CYP2F1, CYP3A4, CYP2A6 | CA9 2223/4885NPC1 1365/4885MAPK13 4647/4885 |
| US-20060258869-A1 | Process for the preparation of aripiprazole | CYP2F1, CYP3A4, CYP2A7 | CA9 2262/4885NPC1 3413/4885MAPK13 4608/4885 |
| US-20060079690-A1 | Processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone and the use in aripiprazole preparation thereof | CYP2A7, CYP3A7, CYP3A5 | CA9 2015/4885NPC1 3796/4885MAPK13 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.