Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.51 |
| ▸ | PTPRF | P10586 | 3/20 | 0.48 |
| ▸ | PTPRA | P18433 | 3/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882720 | 0.86 | KDM4E (0.53) | IKBKBMEN1KMT2AALDH1A1GAA | |
| SCHEMBL874666 | 0.86 | IKBKB (0.55) | PTPN1IKBKBMEN1KMT2APOLB | |
| SCHEMBL613433 | 0.83 | PTPN1 (0.48) | PTPN1PTPRFPTPRAIKBKBMEN1 | |
| SCHEMBL874565 | 0.82 | PTPN1 (0.55) | PTPN1PTPRFPTPRAMEN1KMT2A | |
| SCHEMBL4712938 | 0.79 | PTPN1 (0.78) | PTPN1PTPRFPTPRAIKBKBMEN1 | |
| SCHEMBL875389 | 0.76 | IKBKB (0.60) | PTPN1IKBKBMEN1KMT2APOLB | |
| SCHEMBL613690 | 0.74 | CDC7 (0.59) | IKBKBKMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL611071 | 0.73 | KDM6B (0.50) | PTPN1PTPRFPTPRAIKBKBMEN1 | |
| SCHEMBL3807328 | 0.72 | PTPN1 (0.54) | PTPN1PTPRFIKBKBMEN1KMT2A | |
| SCHEMBL2458721 | 0.72 | NPSR1 (0.58) | IKBKBKDM4EACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |