Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875205 | 0.86 | PTPN1 (0.51) | IKBKBMAPTALDH1A1RAB9AMEN1 | |
| SCHEMBL882720 | 0.84 | KDM4E (0.53) | IKBKBMAPTALDH1A1RAB9AMEN1 | |
| SCHEMBL7051768 | 0.83 | IKBKB (0.64) | IKBKBMAPTHPGDPTPN1 | |
| SCHEMBL874783 | 0.83 | IKBKB (0.48) | IKBKBMAPTALDH1A1RAB9AMEN1 | |
| SCHEMBL874891 | 0.76 | HDAC1 (0.50) | IKBKBMAPTPOLB | |
| SCHEMBL875667 | 0.76 | CD274 (0.42) | MAPTALDH1A1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL613690 | 0.72 | CDC7 (0.59) | IKBKBALDH1A1KMT2AKDM4EMAP4K4 | |
| SCHEMBL874893 | 0.71 | POLB (0.55) | MEN1KMT2ASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL613433 | 0.70 | PTPN1 (0.48) | IKBKBALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7056469 | 0.70 | IKBKB (0.79) | IKBKBMAPTALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |