SCHEMBL8752425

SCHEMBL8752425

CCOc1ccc(NS(=O)(=O)c2ccccc2)cc1

nearest known ligand 0.97

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.97
KMT2A Q03164 4/20 0.97
MAPT P10636 3/20 0.97
LMNA P02545 4/20 0.75
MAPK1 P28482 1/20 0.75
AR P10275 2/20 0.70
ALDH1A1 P00352 6/20 0.69
HTT P42858 1/20 0.69
NPSR1 Q6W5P4 1/20 0.69
PGR P06401 1/20 0.66
SQSTM1 Q13501 1/20 0.64
KEAP1 Q14145 1/20 0.64
NFE2L2 Q16236 1/20 0.64
PKM P14618 2/20 0.62
TDP1 Q9NUW8 1/20 0.62
HPGD P15428 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
ALOX15 P16050 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8752453 0.94 KMT2A (0.91) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL27181064 0.87 KMT2A (0.74) MEN1KMT2AMAPTLMNAALDH1A1
SCHEMBL8752540 0.86 KMT2A (0.78) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL28109022 0.86 MAPT (0.78) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL3369379 0.86 KMT2A (0.78) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL15840640 0.85 MAPT (0.76) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL4953484 0.84 KMT2A (0.76) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL7175067 0.84 KMT2A (0.76) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL12903603 0.84 KMT2A (0.76) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL11364586 0.83 KMT2A (0.69) MEN1KMT2AMAPTLMNAAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0610653-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1997-04-16 EP claimed
US-5444036-A Arylsulfonylureido compound, acetoacetanilide compound, sulfonamide derivative; storage stability NEW OIL PAPER CO., LTD. (JP) 1995-08-22 US claimed
EP-0610653-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-08-17 EP claimed
US-12048316-B2 Sweetener and flavor compositions, methods of making and methods of use thereof EPC NATURAL PRODUCTS CO., LTD. (CN) 2024-07-30 US disclosed
US-12029228-B2 Sweetener and flavor compositions, methods of making and methods of use thereof EPC Natural Products Co., Ltd (CN) 2024-07-09 US disclosed
US-11985994-B2 Sweetener and flavor compositions, methods of making and methods of use thereof EPC Natural Products Co., Ltd (CN) 2024-05-21 US disclosed
US-11849742-B2 Tasteful natural sweetener and flavor EPC NATURAL PRODUCTS CO., LTD. (CN) 2023-12-26 US disclosed
US-11793218-B2 Sweetener and flavor compositions, methods of making and methods of use thereof EPC NATURAL PRODUCTS CO., LTD. (CN) 2023-10-24 US disclosed
EP-4223146-A1 SWEETENER AND FLAVOR COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE THEREOF EPC Natural Products Co., Ltd. (CN) 2023-08-09 EP disclosed
US-20230082165-A1 TASTEFUL NATURAL SWEETENER AND FLAVOR EPC Natural Products Co., Ltd (CN) 2023-03-16 US disclosed
US-20230085263-A1 TASTEFUL NATURAL SWEETENER AND FLAVOR EPC Natural Products., Ltd. (CN) 2023-03-16 US disclosed
WO-2019217269-A1 A TASTEFUL NATURAL SWEETENER AND FLAVOR EPC NATURAL PRODUCTS CO., LTD. (CN) 2019-11-14 WO disclosed
WO-2019217312-A1 SWEETENER AND FLAVOR COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE THEREOF EPC NATURAL PRODUCTS CO., LTD. (CN) 2019-11-14 WO disclosed
US-20090012091-A1 Oximide derivatives and their therapeutical application KINAGEN, INC. (US) 2009-01-08 US disclosed
EP-0610653-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1997-04-16 EP disclosed
US-5444036-A Arylsulfonylureido compound, acetoacetanilide compound, sulfonamide derivative; storage stability NEW OIL PAPER CO., LTD. (JP) 1995-08-22 US disclosed
EP-0610653-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-08-17 EP disclosed
US-4600797-A NITRATING AN AMINOBENZENE WHICH HAS A PROTECTEDD AMINO GROUP BAYER AKTIENGESELLSCHAFT (DE) 1986-07-15 US disclosed
EP-0049711-B1 PROCESS FOR THE PRODUCTION OF NITRO-AMINO-BENZENES BAYER AG (DE) 1984-02-29 EP disclosed
EP-0049711-A1 Process for the production of nitro-amino-benzenes BAYER AG (DE) 1982-04-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012091-A1 Oximide derivatives and their therapeutical application CYP11B2, NOS2, HMOX2 MEN1 3250/4885KMT2A 2137/4885MAPT 2130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.