Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
| ▸ | PPIB | P23284 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875709 | 0.97 | NAMPT (0.44) | NAMPTHDAC1HDAC6KLKB1ACVR1 | |
| SCHEMBL874781 | 0.87 | HDAC6 (0.48) | NAMPTHDAC1HDAC6ROCK2CPB1 | |
| SCHEMBL875615 | 0.87 | NAMPT (0.45) | NAMPTHDAC1HDAC6ROCK2CPB1 | |
| SCHEMBL875268 | 0.82 | NAMPT (0.40) | NAMPTHDAC6ACVR1BRD4KIT | |
| SCHEMBL875269 | 0.82 | NAMPT (0.40) | NAMPTHDAC6ACVR1BRD4KIT | |
| SCHEMBL874150 | 0.77 | HDAC6 (0.48) | HDAC6ACVR1BRD4 | |
| SCHEMBL875445 | 0.76 | NAMPT (0.46) | NAMPTHDAC1KIT | |
| SCHEMBL3050217 | 0.76 | HDAC1 (0.47) | NAMPTHDAC1ROCK2 | |
| SCHEMBL882752 | 0.75 | NAMPT (0.46) | NAMPTHDAC1KLKB1CPB1PPIB | |
| SCHEMBL875705 | 0.75 | NAMPT (0.47) | NAMPTHDAC1ROCK2CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |