Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.41 |
| ▸ | USP1 | O94782 | 1/20 | 0.39 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874781 | 0.90 | HDAC6 (0.48) | NAMPTHDAC1HDAC6ROCK2CPB1 | |
| SCHEMBL875402 | 0.87 | NAMPT (0.45) | NAMPTHDAC1HDAC6ROCK2CPB1 | |
| SCHEMBL875709 | 0.85 | NAMPT (0.44) | NAMPTHDAC1HDAC6ROCK2 | |
| SCHEMBL875445 | 0.76 | NAMPT (0.46) | NAMPTHDAC1 | |
| SCHEMBL3057949 | 0.75 | HDAC1 (0.45) | NAMPTHDAC1ROCK2MOK | |
| SCHEMBL875947 | 0.75 | PPARA (0.49) | NAMPTHDAC1 | |
| SCHEMBL875705 | 0.75 | NAMPT (0.47) | NAMPTHDAC1ROCK2CPB1 | |
| SCHEMBL874907 | 0.74 | NAMPT (0.47) | NAMPTHDAC1 | |
| SCHEMBL875016 | 0.73 | NAMPT (0.41) | NAMPTHDAC1ROCK2CPB1 | |
| SCHEMBL875702 | 0.73 | NAMPT (0.44) | NAMPTHDAC1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |