Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PPIB | P23284 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875402 | 0.97 | NAMPT (0.45) | NAMPTHDAC1KITHDAC6ACVR1 | |
| SCHEMBL875615 | 0.85 | NAMPT (0.45) | NAMPTHDAC1HDAC6ROCK2 | |
| SCHEMBL874781 | 0.85 | HDAC6 (0.48) | NAMPTHDAC1HDAC6ROCK2 | |
| SCHEMBL875268 | 0.79 | NAMPT (0.40) | NAMPTKITHDAC6ACVR1NPC1 | |
| SCHEMBL875269 | 0.79 | NAMPT (0.40) | NAMPTKITHDAC6ACVR1NPC1 | |
| SCHEMBL875445 | 0.76 | NAMPT (0.46) | NAMPTHDAC1KIT | |
| SCHEMBL3042675 | 0.76 | NAMPT (0.45) | NAMPTHDAC1KITACVR1EPHX1 | |
| SCHEMBL874150 | 0.74 | HDAC6 (0.48) | HDAC6ACVR1 | |
| SCHEMBL875705 | 0.73 | NAMPT (0.47) | NAMPTHDAC1ROCK2 | |
| SCHEMBL874894 | 0.73 | NAMPT (0.46) | NAMPTHDAC1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |