SCHEMBL8754136

SCHEMBL8754136

Cc1ccc2ccc(Cl)cc2[n+]1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.37
ALDH1A1 P00352 3/20 0.36
ACHE P22303 1/20 0.36
PTPN1 P18031 1/20 0.36
SMN1; SMN2 Q16637 4/20 0.35
CYP3A4 P08684 3/20 0.35
KDM4E B2RXH2 3/20 0.35
MAPT P10636 3/20 0.35
MEN1 O00255 2/20 0.35
USP2 O75604 2/20 0.35
KMT2A Q03164 2/20 0.35
LMNA P02545 2/20 0.35
HTT P42858 2/20 0.35
APEX1 P27695 1/20 0.35
CASP1 P29466 1/20 0.35
BRCA1 P38398 1/20 0.35
CASP7 P55210 1/20 0.35
HBB P68871 1/20 0.35
HIF1A Q16665 1/20 0.35
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL28574286 0.98 ACHE (0.38) CYP2A6ALDH1A1ACHEPTPN1SMN1; SMN2
SCHEMBL8727736 0.93 ACHE (0.33) CYP2A6ALDH1A1ACHEPTPN1SMN1; SMN2
SCHEMBL10168165 0.86 CYP2A6 (0.40) CYP2A6ALDH1A1ACHEPTPN1SMN1; SMN2
Trifluoromethanesulfonic Acid SCHEMBL4887199 0.83 KCNH2 (0.42) ALDH1A1ACHEKDM4EKCNH2
SCHEMBL6088423 0.78 ALDH1A1 (0.36) CYP2A6ALDH1A1CYP3A4KDM4EMAPT
Iodide SCHEMBL6660743 0.73 KDM4E (0.40) CYP2A6ALDH1A1SMN1; SMN2CYP3A4KDM4E
SCHEMBL384487 0.72 TERT (0.43) CYP2A6ALDH1A1ACHEPTPN1SMN1; SMN2
Trifluoromethanesulfonic Acid SCHEMBL4884747 0.71 KCNH2 (0.41) ACHEKCNH2
SCHEMBL1044982 0.71 ACHE (0.47) CYP2A6ALDH1A1ACHESMN1; SMN2KDM4E
SCHEMBL15632277 0.71 KDM4E (0.39) ALDH1A1ACHESMN1; SMN2CYP3A4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643698-B1 SPECTROPHOTOMETRIC METHODS FOR ASSAYING TOTAL MERCAPTANS, REDUCED GLUTATHIONE (GSH) AND MERCAPTANS OTHER THAN GSH IN AN AQUEOUS MEDIUM, REAGENTS AND KITS FOR THEIR IMPLEMENTATION OXIS INT SA (FR) 1997-03-05 EP claimed
EP-0643698-B1 SPECTROPHOTOMETRIC METHODS FOR ASSAYING TOTAL MERCAPTANS, REDUCED GLUTATHIONE (GSH) AND MERCAPTANS OTHER THAN GSH IN AN AQUEOUS MEDIUM, REAGENTS AND KITS FOR THEIR IMPLEMENTATION OXIS INT SA (FR) 1997-03-05 EP disclosed
WO-1993013071-A1 SPECTROPHOTOMETRIC METHODS FOR ASSAYING TOTAL MERCAPTANS, REDUCED GLUTATHIONE (GSH) AND MERCAPTANS OTHER THAN GSH IN AN AQUEOUS MEDIUM, REAGENTS AND KITS FOR IMPLEMENTING SAME BIOXYTECH (FR) 1993-07-08 WO disclosed