Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964246 | 1.00 | TRPA1 (0.44) | TRPA1TDP1CYP1A2EPHX1CSNK1E | |
| SCHEMBL4964239 | 1.00 | TRPA1 (0.44) | TRPA1TDP1CYP1A2EPHX1CSNK1E | |
| SCHEMBL1598160 | 0.94 | CSNK1E (0.44) | TRPA1TDP1CYP1A2EPHX1CSNK1E | |
| SCHEMBL11297877 | 0.92 | CSNK1E (0.46) | TRPA1TDP1CYP1A2EPHX1CSNK1E | |
| SCHEMBL27622402 | 0.92 | CSNK1E (0.46) | TRPA1TDP1CYP1A2EPHX1CSNK1E | |
| SCHEMBL27890776 | 0.92 | CSNK1E (0.46) | TRPA1TDP1CYP1A2EPHX1CSNK1E | |
| SCHEMBL17075353 | 0.92 | CSNK1E (0.46) | TRPA1TDP1CYP1A2EPHX1CSNK1E | |
| SCHEMBL5097040 | 0.89 | TRPA1 (0.48) | TRPA1CYP1A2EPHX1CSNK1EFOLH1 | |
| SCHEMBL8425091 | 0.87 | TRPA1 (0.47) | TRPA1TDP1CYP1A2EPHX1TSHR | |
| SCHEMBL5868422 | 0.87 | TRPA1 (0.47) | TRPA1TDP1CYP1A2EPHX1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359306-B2 | Process for preparing pan-CDK inhibitors of the formula (I), and intermediates in the preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-06-07 | — | — | US | disclosed |
| US-20130245261-A1 | PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-09-19 | — | — | US | disclosed |
| EP-2619186-A1 | PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION | Bayer Pharma Aktiengesellschaft (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038411-A1 | PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-7230135-B2 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | WARNER LAMBERT COMPANY LLC (US) | 2007-06-12 | — | — | US | disclosed |
| US-7230135-B2 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | WARNER LAMBERT COMPANY LLC (US) | 2007-06-12 | — | — | US | disclosed |
| US-7230135-B2 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | WARNER LAMBERT COMPANY LLC (US) | 2007-06-12 | — | — | US | disclosed |
| EP-1341799-B1 | P-CHIRALE BISPHOSPHOLANE LIGANDS, THEIR TRANSITION METAL COMPLEXES | WARNER LAMBERT CO (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20040215027-A1 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | HOGE GARRETT STEWART | 2004-10-28 | — | — | US | disclosed |
| US-6750171-B2 | IMPROVE ENANTIOSELECTIVITY IN ASYMMETRIC REACTIONS | WARNER-LAMBERT COMPANY LLC | 2004-06-15 | — | — | US | disclosed |
| US-20030236433-A1 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | HOGE GARRETT STEWART (US) | 2003-12-25 | — | — | US | disclosed |
| EP-1341799-A1 | P-CHIRALE BISPHOSPHOLANE LIGANDS, THEIR TRANSITION METAL COMPLEXES | Warner-Lambert Company LLC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6605745-B2 | Locates chirality closer to the metal center than known metal phospholane complexes; provide high enantiomeric excesses of formed compounds | HOGE II GARRETT STEWART (US) | 2003-08-12 | — | — | US | disclosed |
| US-20020087017-A1 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | HOGE GARRETT STEWART (US) | 2002-07-04 | — | — | US | disclosed |
| WO-2002048161-A1 | P-CHIRALE BISPHOSPHOLANE LIGANDS, THEIR TRANSITION METAL COMPLEXES | WARNER-LAMBERT COMPANY LLC (US) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040215027-A1 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | PHOSPHO1, BPGM, PHPT1 | TRPA1 3613/4885TDP1 4683/4885CYP1A2 2096/4885 |
| US-20130245261-A1 | PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION | CDK1, CDK9, CDK6 | TRPA1 4882/4885TDP1 729/4885CYP1A2 1630/4885 |
| US-20030236433-A1 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | PHOSPHO1, BPGM, PHPT1 | TRPA1 3613/4885TDP1 4683/4885CYP1A2 2096/4885 |
| US-20020087017-A1 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts | PHOSPHO1, BPGM, PHPT1 | TRPA1 3613/4885TDP1 4683/4885CYP1A2 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.