Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 11/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875947 | 0.88 | PPARA (0.49) | HDAC1NAMPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL874763 | 0.88 | NAMPT (0.43) | HDAC1NAMPTROCK2ALDH1A1POLB | |
| SCHEMBL874755 | 0.86 | NAMPT (0.47) | HDAC1NAMPTPOLB | |
| SCHEMBL875702 | 0.85 | NAMPT (0.44) | HDAC1NAMPTROCK2ALDH1A1POLB | |
| SCHEMBL875967 | 0.84 | NAMPT (0.40) | HDAC1NAMPTROCK2PPARA | |
| SCHEMBL3057949 | 0.84 | HDAC1 (0.45) | HDAC1NAMPTROCK2MAPKAPK2MTOR | |
| SCHEMBL874752 | 0.77 | NAMPT (0.52) | HDAC1NAMPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3054524 | 0.75 | HDAC1 (0.46) | HDAC1NAMPTROCK2POLB | |
| SCHEMBL882700 | 0.75 | POLB (0.60) | NAMPTALDH1A1POLB | |
| SCHEMBL874813 | 0.74 | NAMPT (0.48) | HDAC1NAMPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |