Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875577 | 0.87 | HDAC1 (0.43) | NAMPTHDAC1MAPKAPK2POLB | |
| SCHEMBL875947 | 0.87 | PPARA (0.49) | NAMPTHDAC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL874795 | 0.86 | NAMPT (0.47) | NAMPTHDAC1 | |
| SCHEMBL875487 | 0.85 | HDAC1 (0.45) | NAMPTHDAC1MAPKAPK2ROCK2ALDH1A1 | |
| SCHEMBL874763 | 0.82 | NAMPT (0.43) | NAMPTHDAC1ROCK2ALDH1A1POLB | |
| SCHEMBL874805 | 0.81 | MAPT (0.43) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL874752 | 0.76 | NAMPT (0.52) | NAMPTHDAC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3057949 | 0.74 | HDAC1 (0.45) | NAMPTHDAC1MAPKAPK2ROCK2 | |
| SCHEMBL874685 | 0.74 | RAB9A (0.46) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL874398 | 0.73 | NAMPT (0.50) | NAMPTHDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |