Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16391277 | 1.00 | CYP2C19 (0.40) | CYP2C19CYP3A4POLBSMN1; SMN2ATM | |
| SCHEMBL7722193 | 0.98 | ALDH1A1 (0.39) | CYP2C19CYP3A4POLBSMN1; SMN2ATM | |
| SCHEMBL4812312 | 0.95 | CYP2C19 (0.43) | CYP2C19CYP3A4POLBSMN1; SMN2ATM | |
| SCHEMBL1858415 | 0.85 | CYP2C19 (0.35) | CYP2C19CYP3A4POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9970859 | 0.84 | ALDH1A1 (0.38) | CYP2C19SMN1; SMN2ATMALDH1A1MEN1 | |
| SCHEMBL20390051 | 0.82 | OPRM1 (0.47) | CYP2C19CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL25046060 | 0.81 | SMN1; SMN2 (0.37) | POLBSMN1; SMN2ATMALDH1A1F10 | |
| SCHEMBL9035301 | 0.81 | CYP2C19 (0.34) | CYP2C19CYP3A4POLBALDH1A1MEN1 | |
| SCHEMBL13012717 | 0.81 | ATM (0.40) | POLBSMN1; SMN2ATMALDH1A1F10 | |
| SCHEMBL14498565 | 0.81 | ALDH1A1 (0.33) | CYP3A4POLBSMN1; SMN2ALDH1A1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720678-A1 | SURVIVIN AS A BIOMARKER FOR PREDICTING THE RESPONSIVENESS OF CANCER TREATMENT | Boehringer Ingelheim International GmbH (DE) | 2026-04-08 | — | — | EP | disclosed |
| US-20250326731-A1 | CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS | SCRIPPS RESEARCH INST (US) | 2025-10-23 | — | — | US | disclosed |
| US-20250313553-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTL GMBH CORP (DE) | 2025-10-09 | — | — | US | disclosed |
| US-20250145608-A1 | KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES | BOEHRINGER INGELHEIM INTL GMBH CORP (DE) | 2025-05-08 | — | — | US | disclosed |
| EP-4522595-A2 | CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS | The Scripps Research Institute (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2024246114-A1 | SURVIVIN AS A BIOMARKER FOR PREDICTING THE RESPONSIVENESS OF CANCER TREATMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-12-05 | — | — | WO | disclosed |
| CN-119013272-A | Cyclic 2-amino-3-cyanothiophenes and derivatives thereof for the treatment of cancer | 勃林格殷格翰国际有限公司 | 2024-11-22 | — | — | CN | disclosed |
| EP-4441051-A1 | KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES | Boehringer Ingelheim International GmbH (DE) | 2024-10-09 | — | — | EP | disclosed |
| EP-4441050-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | Boehringer Ingelheim International GmbH (DE) | 2024-10-09 | — | — | EP | disclosed |
| CN-118591540-A | KRAS degrading compounds comprising cyclic 2-amino-3-cyanothiophenes | 勃林格殷格翰国际有限公司 | 2024-09-03 | — | — | CN | disclosed |
| WO-1999046237-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
| WO-1999046267-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |
| US-4461902-A | BLOOD LIPID AND SUGAR LOWERING AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-07-24 | — | — | US | disclosed |
| EP-0084926-A1 | Thiazolidine derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1983-08-03 | — | — | EP | disclosed |
| US-4128560-A | Tricyclic alkylamine derivatives | AYERST MCKENNA & HARRISON LTD. (CA) | 1978-12-05 | — | — | US | disclosed |
| US-3948939-A | 9-Acyl-1,2,3,4-tetrahydrocarbazole-3 and 4-carboxylic acids | STERLING DRUG INC. (US) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250326731-A1 | CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS | DNPH1, NISCH, PTMA | CYP2C19 2563/4885CYP3A4 2940/4885POLB 2221/4885 |
| US-20250313553-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | KRAS, NRAS, TP53 | CYP2C19 1035/4885CYP3A4 756/4885POLB 1243/4885 |
| US-20250145608-A1 | KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES | KRAS, NRAS, TP53 | CYP2C19 1115/4885CYP3A4 794/4885POLB 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.