SCHEMBL876019

SCHEMBL876019

FC(F)(F)c1cncc(Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 5/20 0.43
ALDH1A1 P00352 3/20 0.40
HCAR2 Q8TDS4 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
PLAU P00749 1/20 0.38
KDM4E B2RXH2 1/20 0.38
POLB P06746 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
HTT P42858 2/20 0.37
NPSR1 Q6W5P4 1/20 0.37
NPC1 O15118 1/20 0.37
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.37
KCNH2 Q12809 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27566786 0.98 CYP19A1 (0.42) CYP19A1ALDH1A1HCAR2TDP1L3MBTL1
Cyanide SCHEMBL27815567 0.94 CYP19A1 (0.43) CYP19A1ALDH1A1HCAR2TDP1L3MBTL1
SCHEMBL29111925 0.92 CYP19A1 (0.39) CYP19A1ALDH1A1HCAR2TDP1L3MBTL1
Alcohol SCHEMBL28895679 0.88 DDR1 (0.41) CYP19A1ALDH1A1HCAR2TDP1L3MBTL1
Acetonitrile SCHEMBL27979099 0.88 CYP11B1 (0.42) CYP19A1ALDH1A1TDP1L3MBTL1KDM4E
Formic Acid SCHEMBL28229618 0.88 LMNA (0.42) CYP19A1ALDH1A1HCAR2L3MBTL1PLAU
Acetic Acid SCHEMBL28557709 0.87 HCAR2 (0.47) CYP19A1ALDH1A1HCAR2KDM4EPOLB
Acetamide SCHEMBL28112655 0.85 ALDH1A1 (0.47) ALDH1A1HCAR2PLAUKDM4ESMN1; SMN2
SCHEMBL27314240 0.82 TLR8 (0.45) TDP1L3MBTL1HTT
Propionic Acid SCHEMBL28134495 0.82 AGBL2 (0.45) ALDH1A1HCAR2L3MBTL1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 367 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119219553-A Synthesis method of 3-chloro-2-aminoethyl-5-trifluoromethyl pyridine 江苏快达农化股份有限公司 2024-12-31 CN claimed
CN-119118917-A Allyl thiourea preparation process capable of reducing metal corrosion rate 浙江鑫甬生物化工股份有限公司 2024-12-13 CN claimed
CN-114031551-B Fluopicolide and synthesis method thereof 利民化学有限责任公司 2023-07-25 CN claimed
CN-116283753-A Trifluoromethyl pyridine amide derivative and preparation method and application thereof 武汉朗克环境科技有限公司 2023-06-23 CN claimed
CN-110498766-B Fluazinam hapten, artificial antigen and antibody, and preparation method and application thereof 北京勤邦生物技术有限公司 2022-07-08 CN claimed
CN-111333569-B Preparation method and application of cyanoacrylate containing 5-trifluoromethyl-3-chloropyridine biaryloxy unit 南通大学 2022-02-15 CN claimed
CN-114031551-A Fluopyram and synthesis method thereof 利民化学有限责任公司 2022-02-11 CN claimed
CN-111333569-A Preparation method and application of cyanoacrylate containing 5-trifluoromethyl-3-chloropyridine biaryloxy unit 南通大学 2020-06-26 CN claimed
CN-110143916-A A kind of synthesis technology of fluazinam 大连九信精细化工有限公司 2019-08-20 CN claimed
CN-107954924-A A kind of preparation method of the fluoro- 3- chloro-5-trifluoromethylpyridines of 2- 内蒙古佳瑞米精细化工有限公司 2018-04-24 CN claimed
CN-1077792-C Pyridyl bisphosphonates for use as therapeutic agents LEIRAS OY (FI) 2002-01-16 CN claimed
CN-1149830-A Pyridylbisphosphonates for use as therapeutical agent LEIRAS OY (FI) 1997-05-14 CN claimed
EP-0078410-B1 PROCESS FOR PRODUCING 3-CHLORO-5-TRIFLUOROMETHYLPYRIDINES ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-05-27 EP claimed
EP-0074192-B1 CHLORO-TRIFLUOROMETHYL PYRIDINES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-12-30 EP claimed
US-4490534-A CHLORINATION IN VAPOR PHASE, PRESENCE OF CATALYST ISHIHARA SANGYO KAISHA LTD. (JP) 1984-12-25 US claimed
US-4448967-A CHLORINATION OF 3-TRIFLUOROMETHYLPYRIDINE OR 2-CHLORO-5-TRIFLUOROMETHYLPYRIDINE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-05-15 US claimed
US-4429132-A FROM 3-PICOLINE IN PRESENCE OF METAL OXIDE OR HALIDE CATALYST IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-01-31 US claimed
EP-0078410-A2 Process for producing 3-chloro-5-trifluoromethylpyridines ISHIHARA SANGYO KAISHA, LTD. (JP) 1983-05-11 EP claimed
EP-0074192-A2 Chloro-trifluoromethyl pyridines IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-03-16 EP claimed
EP-0065358-A1 Production of 3-trichloromethyl- and 3-trifluoromethyl-pyridines IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-24 EP claimed