Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8758984 | 0.81 | POLB (0.47) | POLBPTPN1LMNATDP1KDM4E | |
| SCHEMBL9063248 | 0.80 | PTPN1 (0.58) | POLBPTPN1KDM4ECYP1A2ADRB2 | |
| SCHEMBL8759552 | 0.78 | SLC6A4 (0.51) | — | |
| SCHEMBL8759406 | 0.77 | KDM4E (0.50) | POLBLMNAKDM4ECYP1A2CYP2D6 | |
| SCHEMBL12377127 | 0.74 | POLB (0.64) | POLBLMNATDP1KDM4ECYP1A2 | |
| SCHEMBL10839377 | 0.74 | POLB (1.00) | POLBLMNAKDM4ECYP1A2GLA | |
| SCHEMBL8759510 | 0.74 | ALDH1A3 (0.51) | LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8758970 | 0.73 | POLB (0.46) | POLBPTPN1LMNAKDM4ECYP1A2 | |
| SCHEMBL8635260 | 0.72 | POLB (0.45) | POLBPTPN1LMNAKDM4ECYP1A2 | |
| SCHEMBL8634980 | 0.72 | CYP2C9 (0.46) | POLBPTPN1SMN1; SMN2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652884-B1 | PHOSPHONATED ARYLETHANOLAMINE COMPOUNDS WITH ANTI-HYPERGLYCEMIC AND/OR ANTI-OBESITY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1997-05-28 | — | — | EP | disclosed |
| US-5519006-A | Phosphonated arylethanolamine compounds with anti-hyperglycemic and/or anti-obesity activity | SMITHKLINE BEECHAM PLC (GB) | 1996-05-21 | — | — | US | disclosed |