Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698534 | 0.84 | MAPT (0.48) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8761568 | 0.81 | L3MBTL1 (0.45) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18526976 | 0.76 | NPC1 (0.52) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8762060 | 0.73 | MAPK14 (0.41) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31643956 | 0.73 | ERN1 (0.48) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12743253 | 0.73 | MAPT (0.57) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8820053 | 0.72 | MAPK14 (0.40) | NPC1RAB9ACCNB2CDK1CDK4 | |
| SCHEMBL16636731 | 0.72 | CCNB2 (0.44) | MAPTL3MBTL1NPC1TDP1MAPK1 | |
| SCHEMBL31643554 | 0.72 | L3MBTL1 (0.45) | MAPTL3MBTL1SMN1; SMN2TDP1MAPK1 | |
| SCHEMBL697364 | 0.72 | NPC1 (0.46) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791266-B2 | Thyroid hormone β receptor agonist | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2014-07-29 | — | — | US | disclosed |
| US-8791266-B2 | Thyroid hormone β receptor agonist | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2014-07-29 | — | — | US | disclosed |
| US-8748620-B2 | — | — | 2014-06-10 | — | — | US | disclosed |
| US-8748620-B2 | — | — | 2014-06-10 | — | — | US | disclosed |
| US-20120129812-A1 | NOVEL THYROID HORMONE BETA RECEPTOR AGONIST | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-24 | — | — | US | disclosed |
| US-20120129812-A1 | NOVEL THYROID HORMONE BETA RECEPTOR AGONIST | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-24 | — | — | US | disclosed |
| EP-2423194-A1 | NOVEL THYROID HORMONE beta RECEPTOR AGONIST | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122980-A1 | NOVEL THYROID HORMONE Β RECEPTOR AGONIST | 田辺三菱製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129812-A1 | NOVEL THYROID HORMONE BETA RECEPTOR AGONIST | THRB, TSHR, THRA | MAPT 2650/4885L3MBTL1 4375/4885SMN1; SMN2 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.